Studies on an Oncostatic Agent ”K.C.G.''

1. An oncostaaic agent ”K.C.G'' was a metabolic product of Seratia marcens,containing bacterial polysaccharide. 2. The polysaccharide rich mutant strain of Serratia marcescens induced by Cdtreatment. 3. Toxity of ”K.C.G.'' was extremely weak, especially in the hematological field.Leukopenia was never caused by ”K.C.G.'' 4. Pyrogenic reactions were observed in clinical experiments as well as animal experiments. 5. In the histological researches, it was proved that ”K.C.G.'' did effect on alveolar wall of lung and genital gland. 6. Oncostatic activities of ”K.C.G'' were confirmed on the Ehrlich ascites tumor (ascitic & solid) in mice. 7. It was proved that ”K.C.G.'' had degenerative activity for Ehrlich tumor cell remarkably. 8. Life-prolongation of tumor-bearing mouse by K.C.G.-treatment was observed. 9. In July, 1960, the first clinical experiment was made by Dr.Hishikawa, Wakayama City. He tried this agent to a severe case of metastatic born cancer originated from breast, in which a surprising effect was observed both clinically and roentgenographically.