Research on the Test of Hepatic Function with Chromazurol S.　- Report Ⅲ. Relationship between hitological changes caused by caebon tetrachloride and hepatic function tests in goats.-

The relationship between liver functions and morphology of the liver based on needlebiopsy was studied in goats following CCL4 administration.　 CONCLUSIONS 1) The chromazurol S retention test in blood was found to be closely correlated with liver morphology as studied by fat, RNA and glycogen staining during an early stage of CCL4 intoxication. 2) Chromazurol S retention test is superior to other established tests except that the recovery of retention occurs rather early as judged from histlogical findings of the liver. 3) There is a good correation between fructose tolerance and disappearance of glycogen from the central zone of the lobule. 4) The various tests for protein metabolism did not have any clear correlation with other function tests or histlogical distribution of RNA. 5) Bromsulphalein retention test reflected degenerative changes in peripheral zone of the lobule but its return to normaloccurred earlier than that of histology.