A case of unilateral atrophic pyelonephritis with compensatory hypertrophy of the contralateral kidney was described with a special reference to juxtaglomerular cells and intertubular cell islets. The chronic infection in the right kidney probably originated in early infancy on the basis ofcongenital structural abnormalities. In this kidney, the epitheloid cells were found to be increased in the preglomerular arterioles and the interlobular arteries. Such increase may be a morphological expression of a reduced intrarenal blood pressure. The intertubular cell islets, on the other hand, were observed only in the left kidney. Their role seems to be a compensatory one, even if they were related to hypertension in some unknown manner.