To assess non-invasively whether the location,extent and severity of left ventricular (LV) contraction abnoumalities affect LV relaxation, we studied apexcardiogram (ACG) in 48 patients with coronary artery disease (CAD) of over 75% luminar stenosis and 16 control subjects under basal conditions within a week before cardiac catheterization. Asynergy of LV wall motion was classified on the basis of AHA committee ventriculography reporting system. The patients consisted of control sudjects [Group I:n=16]and the patients with CAD of one-vessel disease in right coronary artery or left circumflex coronary artery stenosis[Group II