The validity of the commercially available electrode for measurement of transcutaneous oxygen partial pressure (tcPO2), Clark type electrode with polyethylene membrane (Oxygen Monitor 632), during anesthesia was examined. Firstly, the interference of anesthetics with this tcPO2 electrode was examined in vitro, and no interference of nitrous oxide (N2O), halopthane and enflurane was found at clinically used concentrations. Then, the correlation between tcPO2 and PaO2 was examined in 31 adult patients during anesthesia (in vivo study). There was a good correlation between tcPO2 and PaO2 with correlation coefficient of 0.91, 0.79 and 0.94 in the halothane+N2O, neuroleptanalgesia+N2O and enflurane+N2O anesthesia group, responctively, and the regression equation was PaO2=1.37tcPO2-21.7,PaO2=1.39tcPO2-25.3 and PaO2=1.23tcPO2+10.2, respectively. It is concluded that the tcPO2 electrpde tested in the present study is useful in adults during anesthsia.