An Experimental Study of the Neointima of Synthetic Vascular　Prosthesis

Synthetic Prosthesis as substisute for arteries is more desirable than homograft or heterograft, because in incites no degenerative changes that weaken the wall with occasional rupture or obstruct the lumen with resulting thrombosis. Houever, it has the disadvantage of defective initimal lining which promotes occurrence of mural thrombi by the early or late periods. In this paper the objective whether the fibrous tissue or the fibrin plays a leading role in the development of the neointima was discussed and our deviced pre-incorporated prosthesis was described. While the synthetic prosthesis inserted in the subcutaneous tissue was incorporated by the host's fibrous tissue and elicited internal layer consisting of hyalinized fibrous tissue resembled the neointima developed after vascular replacement (Groupe 1), the prosthesis which has been wrapped with polyethylene-film to make it impermeable could not affix to the host's tissue and had defective fibrin lining which caused delayed hematoma and mural thrombus to occur (Groupe 2). The assumption that synthetic prosthesis serves as a strut for ingrowth of the fibrous tissue and porosity is essential to allow the fibrous incorporation seems probably correct. Although our deviced pre-incorporated prosthesis will have await further observation, it is likely that this prosthesis contributes to decrease occurrence of mural thombi and delayed hematoma.