The bulletin of the Yamaguchi Medical School
Continued by：Medical Science & Innovation
EISSN：2758-5441
Back to Top
Permalink : https://petit.lib.yamaguchi-u.ac.jp/16388
The bulletin of the Yamaguchi Medical School Volume 56 Issue 3-4
published_at 2009
Identification of the copy number aberrations for determining the disease stage of colorectal cancers : the application of a multifactor dimensionality reduction (MDR) method to an array-based CGH
Identification of the copy number aberrations for determining the disease stage of colorectal cancers : the application of a multifactor dimensionality reduction (MDR) method to an array-based CGH
About This Article
Descriptions
The clinical application of array CGH technology is eagerly awaited. It is necessary to clarify the genome markers closely associated with the clinical condition. The multifactor dimensionality reduction method (henceforth, MDR) analysis was applied to the array CGH data of 74 cases colorectal cancer in order to identify two or more spot clones, i.e., a clone marker, with the maximum separation ability between low stage and a high stage lesions. The optimal marker in one clone was 8q24.3 (Accuracy 0.7027, Sensitivity 0.9688, Specificity 0.5000), the optimal markers in two clones were 7q36.3 and 22q11.1 (Acc. 0.8108, Sen. 0.8438, Spe. 0.7857)…
Creator Keywords
array based CGH
multifactor dimensionality reduction (MDR) method
cross validation test
Other Article