Primary malignant melanoma of the female urethra is extremely rare with poor porognosis. In 1976, Jeffrey reviewed the literature and found a total of 34 cases. The case reported herein is of interest for the reason that the patint is living without any evidence of recurrence over 36 month after a combined therapy of cryosurgery, topical administrations of Bleomycin, and active immunotherapy with BCG and a streptococcal agent.