Computerized Tomography in Epilepsy

The effects of sciatic nerve stimulation on the cerebral metabolic rate for oxygen (CMRo_2), cerebral blood flow (CBF) and electroencephalogram (EEG) were investigated in anesthetized dogs. With 0.12 and 0.25 per cent methoxyflurane, the CMRo_2 increased by 10 and 13 per cent, being accompanied by EEG activation, and the CBF increased by 8 and 17 per cent, respectively. With 0.38 per cent methoxyflurane, the CMRo_2 and EEG remained unchanged, but the CBF increased by 8 per cent. With 0.5 and 1.5 mg/kg morphine, the CMRo_2 increased by 13 and 12 per cent, being accompanied by EEG activation, and the CBF increased by 15 and 11 per cent, respectively. Addition of 60 per cent nitrous oxide to 1.5 mg/kg morphine increased the CMRo_2, being accompanied by EEG activation, and CBF by 12 and 24 per cent, respectively. These results suggest that the coupling of CMRo_2 and EEG was maintained in all anesthetic circumstances but the coupling of CMRo_2 and CFB was lost with 0.38 per cent methoxyflurane and morphine-nitrous oxide anesthesia.