Background: Delirium is a common problem in intensive care units (ICUs) and is associated with poor outcomes. The association between inflammation and delirium in the peri-extubation period of mechanical ventilation (MV) is poorly understood. Methods: We conducted a prospective, observational study of adult patients on MV for >48 hours in an ICU. At extubation (0 h) and 24 h later, the Confusion Assessment Method for the ICU (CAM-ICU) and the following serum biomarkers were assessed:C-reactive protein (CRP), procalcitonin, white blood cell (WBC) count, interleukin (IL)-6 and -8. Patients were classified into delirious (D
delirium,
mechanical ventilation
Confusion Assessment Method for the Intensive Care Unit
inflammation
C-reactive protein