The bulletin of the Yamaguchi Medical School

Continued by:Medical Science & Innovation
EISSN:2758-5441

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The bulletin of the Yamaguchi Medical School Volume 62 Issue 1-2
published_at 2015

Systemic inflammation and delirium in the periextubation period of mechanical ventilation : an observational prospective study of intensive care unit patients

Systemic inflammation and delirium in the periextubation period of mechanical ventilation : an observational prospective study of intensive care unit patients
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Background: Delirium is a common problem in intensive care units (ICUs) and is associated with poor outcomes. The association between inflammation and delirium in the peri-extubation period of mechanical ventilation (MV) is poorly understood. Methods: We conducted a prospective, observational study of adult patients on MV for >48 hours in an ICU. At extubation (0 h) and 24 h later, the Confusion Assessment Method for the ICU (CAM-ICU) and the following serum biomarkers were assessed:C-reactive protein (CRP), procalcitonin, white blood cell (WBC) count, interleukin (IL)-6 and -8. Patients were classified into delirious (D
Creator Keywords
delirium,
mechanical ventilation
Confusion Assessment Method for the Intensive Care Unit
inflammation
C-reactive protein