The α-helix coiled-coil rod homologue (HCR) gene is known to be associated with the susceptibility of various races to psoriasis vulgaris (PV). This study aimed to analyze single-nucleotide polymorphisms (SNPs) in HCR in Japanese PV patients and investigate the association between these SNPs and PV in the Japanese population. The PV group comprised 75 PV patients from our hospital