The bulletin of the Yamaguchi Medical School

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EISSN:2758-5441

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The bulletin of the Yamaguchi Medical School Volume 52 Issue 1-2
published_at 2005-06

A Case of Therapy-resisutant Idipathic Hypereosinophilic Syndrome with Severe Disseminated Instravascular Coagulation

A Case of Therapy-resisutant Idipathic Hypereosinophilic Syndrome with Severe Disseminated Instravascular Coagulation
Takahashi Toru
Fukuda Naoki
Sato Yutaka
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A020052000102.pdf
Descriptions
Dissaminated intravascular coagulation (DIC) is a rare complication of idiopathic hypereosinophilic syndorome (HES). We report a case of therapy-resistant HES complicated with DIC, in which the sequential profile of vascular endothelial adhesion molecule, eosinophil granule proteins, and several cytokines during clinical course were observed. Serum proteins derived from eosinophil granule and serum soluble vascular cell adhesion molecule 1 had elevated and fluctuated along with the eosinophilia and DIC. The level of serum tumor necrosis factor-α, which stimulates eosinophil attachment to endothelium, was also high in overt DIC. These findings suggest that there may be strong interactions between eosinophils and vascular endothelium and that adhernce of eosinophils to endothelium and production of eosinophil granule proteins may contribute to the development of DIC in HES.
Creator Keywords
hypereosinophilic syndrome
disseminated intravascular coagulation
eosinophil granule proteins
cytokines