A Case of Therapy-resisutant Idipathic Hypereosinophilic Syndrome with Severe Disseminated Instravascular Coagulation
The bulletin of the Yamaguchi Medical School Volume 52 Issue 1-2
Page 15-19
published_at 2005-06
Title
A Case of Therapy-resisutant Idipathic Hypereosinophilic Syndrome with Severe Disseminated Instravascular Coagulation
Source Identifiers
Creator Keywords
hypereosinophilic syndrome
disseminated intravascular coagulation
eosinophil granule proteins
cytokines
Dissaminated intravascular coagulation (DIC) is a rare complication of idiopathic hypereosinophilic syndorome (HES). We report a case of therapy-resistant HES complicated with DIC, in which the sequential profile of vascular endothelial adhesion molecule, eosinophil granule proteins, and several cytokines during clinical course were observed. Serum proteins derived from eosinophil granule and serum soluble vascular cell adhesion molecule 1 had elevated and fluctuated along with the eosinophilia and DIC. The level of serum tumor necrosis factor-α, which stimulates eosinophil attachment to endothelium, was also high in overt DIC. These findings suggest that there may be strong interactions between eosinophils and vascular endothelium and that adhernce of eosinophils to endothelium and production of eosinophil granule proteins may contribute to the development of DIC in HES.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
2005-06
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部