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Journal of higher education Volume 22 pp. 85 - 88
published_at 2025-03
Creators : Fujiwara Isamu Torigoe Kaoru Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22 pp. 61 - 64
published_at 2025-03
Creators : Fujiwara Isamu Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22 pp. 54 - 60
published_at 2025-03
Creators : Yuasa Shuichi Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22 pp. 47 - 53
published_at 2025-03
Creators : Nagai Ryoko Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22 pp. 28 - 36
published_at 2025-03
Creators : Nakano Sachiko Tanaka Tomoko Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22 pp. 15 - 27
published_at 2025-03
Creators : Hayashi Hiroko Toyama Sayaka Jinnouchi Mirai Yamamoto Iwako Hanado Naoko Publishers : Organization for Education and Student Affairs
Creators : Horike Yoshitsugu Publishers : Faculty of Education, Yamaguchi University
Creators : Uehara Kazuaki Agari Hideyuki Publishers : Faculty of Education, Yamaguchi University
Creators : Chen Wang Lei Shi Ge Qi-Wei Quan Gan Publishers : Faculty of Education, Yamaguchi University
Creators : Ito Masataka Kitamoto Takuya Publishers : Faculty of Education, Yamaguchi University
Creators : Sakaguchi Chikara Kasahara Mami Yamanaka Akira Kitazawa Chisato Publishers : Faculty of Education, Yamaguchi University
Creators : Saito Masaki Yoshikai Kaoru Publishers : Faculty of Education, Yamaguchi University
Creators : Ishii Yuri Publishers : Faculty of Education, Yamaguchi University
Creators : Satake Keisuke Kaneko Shuhei Shimoda Yoshiyuki Publishers : Faculty of Education, Yamaguchi University
Creators : Abe Arata Publishers : 山口大学国際総合科学部研究推進委員会
Creators : Kitanishi Koichi Publishers : 山口大学国際総合科学部研究推進委員会
Creators : Kasuga Yumi Kobayashi Nao Nagaya Kazuhisa Publishers : Faculty of Education, Yamaguchi University
Creators : Akiya Naonori Publishers : 山口大学国際総合科学部研究推進委員会
Creators : Sugii Manabu Publishers : 山口大学国際総合科学部研究推進委員会
The journal of Yamaguchi area studies Volume 21 pp. 17 - 36
published_at 2024-03-31
Creators : Yamaguchi Mutsumi Publishers : The association for Yamaguchi area studies
Medical Science & Innovation Volume 72 Issue 1-2 pp. 33 - 42
published_at 2025-06
Hypothermia and focal brain cooling (FBC) demonstrate neuroprotective effects in ischemic stroke, but their invasiveness limits clinical use. We explored transient receptor potential (TRP) channels as an alternative, focusing on TRP Ankyrin 1 (TRPA1), which operates within the temperature range of FBC. Activation of TRPA1 has been reported to offer neuroprotection, suggesting it may contribute to the effects seen with FBC. We hypothesized that pharmacological activation of TRPA1 could replicate the neuroprotective effects of FBC, providing a less invasive treatment for cerebral infarction. We examined the effects of a TRPA1 agonist and FBC in focal cerebral ischemia induced by photochemically triggered thrombosis in wild-type (WT) and TRPA1 knockout (KO) mice. In WT mice, intracerebroventricular administration of the TRPA1 agonist allyl isothiocyanate reduced infarct size by approximately half, comparable to FBC. TRPA1 KO mice had larger infarcts than WT, but FBC significantly reduced infarct size in both groups. Furthermore, Evans blue extravasation, used to assess the extent of blood-brain barrier disruption, was approximately twice as high in TRPA1KO mice compared to WT mice. These findings underscore the neuroprotective potential of TRPA1 agonists and the increased vulnerability against ischemia with TRPA1 deficiency. However, the neuroprotective effects of TRPA1 activation are likely mediated by a mechanism distinct from that of FBC. Our study suggests TRPA1 channels are crucial for ischemic stroke protection and may offer a novel therapeutic approach.
Creators : Okazaki Koki Oka Fumiaki Moriyama Hiroshi Mori Naomasa Nishimoto Takuma Inoue Takao Suzuki Michiyasu Nomura Sadahiro Ishihara Hideyuki Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 72 Issue 1-2 pp. 21 - 31
published_at 2025-06
Focal brain cooling (FBC) at 15℃ and transient receptor potential vanilloid 4 (TRPV4) deficiency relieve brain infarction. TRPV4 channels are inactivated by cooling (< 27℃), suggesting that the anti-ischemic effects of FBC include those of TRPV4 inactivation. However, the extent to which TRPV4 inactivation contributes to the anti-ischemic, anti- blood-brain barrier (BBB) disruption, and anti-apoptosis effects of FBC on cerebral infarction remains unclear. We investigated the contribution and mechanisms of RN1734, a TRPV4 antagonist, in FBC for cerebral infarction using TRPV4 knockout and wild-type mice. Focal cerebral infarction was induced by photochemically induced thrombosis. Infarct volume, BBB disruption, and number of apoptotic cells were evaluated. The TRPV4 antagonist or deficiency showed similar anti-ischemic and anti-BBB disruptive effects to those of FBC. Intracerebroventricular injection of RN1734 showed a similar reduction in the number of apoptotic cells to that of FBC. These anti-ischemic and -apoptotic effects were completely inhibited with injection of GSK1016790A, a TRPV4 agonist, immediately before FBC. Our results showed that TRPV4 modulation is the primary factor contributing to the antiischemic effects of FBC, and TRPV4 channel inactivation relieve focal ischemic infarction by relieving BBB disruption and preventing apoptosis. Therefore, FBC treatment improves ischemic stroke through the modulation of TRPV4 channels.
Creators : Mori Naomasa Moriyama Hiroshi Okazaki Koki Oka Fumiaki Fujiyama Yuichi Shinoyama Mizuya Nomura Sadahiro Inoue Takao Suzuki Michiyasu Ishihara Hideyuki Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 72 Issue 1-2 pp. 13 - 20
published_at 2025-06
A 70-year-old woman presented with acute fever, impaired consciousness, leukopenia, thrombocytopenia, and right inguinal lymphadenopathy. A lymph node biopsy was diagnosed as diffuse large B-cell lymphoma (DLBCL). However, her symptoms were consistent with severe fever with thrombocytopenia syndrome (SFTS), and RT-PCR for SFTS virus (SFTSV) RNA was positive. The patient’s condition and lymphadenopathy gradually improved with supportive measures and short-term steroid treatment and no lymphadenopathy recurrence was observed. Lymph node pathological examination revealed SFTSV-infected cells, leading to the final diagnosis of necrotizing lymphadenitis associated with SFTS. Careful consideration is required to differentiate necrotizing lymphadenitis associated with SFTS from that associated with DLBCL.
Creators : Ando Taishi Nakano Kohei Hayashi Shunsuke Yamashita Kohji Hatao Katsuhiro Yamashita Yoshimi Hirata Yuichiro Mine Sohtaro Katano Harutaka Suzuki Tadaki Takahashi Toru Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 72 Issue 1-2 pp. 7 - 11
published_at 2025-06
Blood-brain barrier (BBB) dysfunction found in the multiple sclerosis (MS) cases is generally considered as a consequence of neuroinflammation. In this study we challenge this view by developing and analyzing novel BBB model from MS patients using induced pluripotent stem cells (iPSCs). We differentiated iPSCs into brain microvascular endothelial cell (BMEC)-like cells to establish an in vitro BBB model. We found that BMEC-like cells from MS patients exhibited compromised barrier integrity, characterized by weakened junctions, heightened permeability, and an elevated inflammatory profile when compared to cells from healthy individuals. Notably, the activation of the Wnt/β-catenin signaling pathway led to improvements in barrier function and a reduction in inflammatory responses, indicating potential therapeutic targets for reinforcing BBB stability in MS.
Creators : Nishihara Hideaki Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 72 Issue 1-2 pp. 1 - 5
published_at 2025-06
Cardiac hypertrophy is widely recognized as a significant risk factor contributing to adverse outcomes in individuals with cardiovascular conditions. The disruption of intracellular calcium ( Ca^{2+} ) balance has been implicated in the development of cardiac hypertrophy, though the precise mechanisms remain poorly understood. In this research, we explored whether hypertrophy induced by pressure overload may arise from the destabilization of the cardiac ryanodine receptor (RyR2) triggered by the dissociation of calmodulin (CaM), leading to subsequent Ca^{2+} leakage. We also assessed whether genetically strengthening the binding affinity between CaM and RyR2 could potentially reverse this process. In the early phases of cardiac hypertrophy caused by pressure overload—when contractile function is still intact—we observed that RyR2 destabilization mediated by reactive oxygen species (ROS) coincides with impaired relaxation. Moreover, stabilizing RyR2 through enhanced CaM binding was found to completely inhibit hypertrophic signaling and improve survival rates. Our findings reveal a crucial connection between RyR2 destabilization and the progression of cardiac hypertrophy.
Creators : Kohno Michiaki Kobayashi Shigeki Yamamoto Takeshi Yano Masafumi Publishers : Yamaguchi University School of Medicine
The journal of Yamaguchi area studies Volume 20 pp. 13 - 28
published_at 2023-03-31
Creators : Kuwahata Yoichiro Publishers : The association for Yamaguchi area studies
The journal of Yamaguchi area studies Volume 20 pp. 1 - 12
published_at 2023-03-31
Creators : Hayashi Hiroko Publishers : The association for Yamaguchi area studies
The journal of Yamaguchi area studies Volume 19 pp. 55 - 67
published_at 2022-03-31
Creators : Hayashi Hiroko Publishers : The association for Yamaguchi area studies
Creators : Tsuneyoshi Tetsuzo Publishers : 山口大学大学院教育学研究科附属臨床心理センター
Yamaguchi Daigaku dokufutsu bungaku Volume 46 pp. 55 - 61
published_at 2024-12-25
Creators : Shimosaki Masatoshi Publishers : Yamaguchi University German & French Literature Research Society
Yamaguchi Daigaku dokufutsu bungaku Volume 46 pp. 31 - 53
published_at 2024-12-25
Creators : Takemoto Masashi Publishers : Yamaguchi University German & French Literature Research Society
Yamaguchi Daigaku dokufutsu bungaku Volume 46 pp. 1 - 29
published_at 2024-12-25
Creators : De Boissieu Michel Publishers : Yamaguchi University German & French Literature Research Society
山口大学学生相談所年報 Volume 33 pp. 36 - 44
published_at 2025-03-31
Creators : Kasuga Yumi Publishers : 山口大学教育・学生支援機構学生支援センター
山口大学学生相談所年報 Volume 33 pp. 5 - 11
published_at 2025-03-31
Creators : Hironaka Kyoko Publishers : 山口大学教育・学生支援機構学生支援センター
山口大学学生相談所年報 Volume 33 pp. 2 - 4
published_at 2025-03-31
Creators : Motoyoshi Sayo Publishers : 山口大学教育・学生支援機構学生支援センター
Creators : Kashiwaki Yasuko Publishers : Yamaguchi University Philosophical Research Society
Creators : Alam Djumali Publishers : Yamaguchi University Philosophical Research Society
Creators : Kurihara Go Publishers : Yamaguchi University Philosophical Research Society
Journal of cross-cultural studies Volume 19 pp. 99 - 108
published_at 2025-03-31
Creators : Takenaka Koji Publishers : The Cross-Cultural Interchange & Research Institute
Creators : Kobayashi Hiroshi Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Journal of cross-cultural studies Volume 19 pp. 87 - 98
published_at 2025-03-31
Creators : Kawai Hironao Publishers : The Cross-Cultural Interchange & Research Institute
Creators : 朱 瑩 Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Creators : 古屋 真央 Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Creators : Kuroha Ryota Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Creators : Ueda Yukiko Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Journal of cross-cultural studies Volume 19 pp. 53 - 69
published_at 2025-03-31
Creators : Abe Yasuki Publishers : The Cross-Cultural Interchange & Research Institute
Journal of cross-cultural studies Volume 19 pp. 35 - 52
published_at 2025-03-31
Creators : Kuwahata Yoichiro Publishers : The Cross-Cultural Interchange & Research Institute