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departmental bulletin paper
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Journal of higher education Volume 22
pp. 85 - 88
published_at 2025-03
Journal of higher education Volume 22
pp. 80 - 84
published_at 2025-03
Creators :
Kondo Kei
Onimura Kenjiro
Fujiwara Isamu
森本 宏志
Funamoto Daiki
Komemoto Tomomi
Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22
pp. 71 - 79
published_at 2025-03
Creators :
Morifuku Orie
Umemoto Tomoko
Nakahara Atsuko
Kobayashi Kumi
Fujikatsu Ayaka
Higuchi Naoko
Fukue Noriko
Nagao Yuko
Yamamoto Naoki
Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22
pp. 65 - 70
published_at 2025-03
Creators :
Okada Nahoko
Sakurai Rin
Yanagishita Masako
Matsuo Rika
Tanaka Miho
Tanaka Ayami
Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22
pp. 61 - 64
published_at 2025-03
Journal of higher education Volume 22
pp. 54 - 60
published_at 2025-03
Journal of higher education Volume 22
pp. 47 - 53
published_at 2025-03
Journal of higher education Volume 22
pp. 37 - 46
published_at 2025-03
Creators :
Takemoto Marie
Hayashi Hiroko
Publishers : Organization for Education and Student Affairs
Journal of higher education Volume 22
pp. 28 - 36
published_at 2025-03
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 233 - 241
published_at 2025-03-28
Journal of higher education Volume 22
pp. 15 - 27
published_at 2025-03
Creators :
Hayashi Hiroko
Toyama Sayaka
Jinnouchi Mirai
Yamamoto Iwako
Hanado Naoko
Publishers : Organization for Education and Student Affairs
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 223 - 232
published_at 2025-03-28
Journal of higher education Volume 22
pp. 1 - 14
published_at 2025-03
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 211 - 221
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 201 - 209
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 191 - 199
published_at 2025-03-28
Creators :
Takahashi Masako
Okibayashi Yohei
Ishida Chiharu
Publishers : Faculty of Education, Yamaguchi University
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 185 - 190
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 179 - 183
published_at 2025-03-28
A Proposal of an Internal Organs Classification Model Based on Tongue Images and Tongue Descriptions
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 173 - 178
published_at 2025-03-28
Creators :
Chen Wang
Lei Shi
Ge Qi-Wei
Quan Gan
Publishers : Faculty of Education, Yamaguchi University
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 163 - 171
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 153 - 162
published_at 2025-03-28
Creators :
Sakaguchi Chikara
Kasahara Mami
Yamanaka Akira
Kitazawa Chisato
Publishers : Faculty of Education, Yamaguchi University
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 143 - 152
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 133 - 141
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 123 - 132
published_at 2025-03-28
Creators :
Matsuura Minako
Matsuoka Katsuhiko
Publishers : Faculty of Education, Yamaguchi University
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 119 - 122
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 113 - 117
published_at 2025-03-28
Creators :
Suto Kunihiko
Miyaki Hideo
Matsuoka Katsuhiko
Publishers : Faculty of Education, Yamaguchi University
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 103 - 112
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 93 - 102
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 85 - 91
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 79 - 84
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 71 - 78
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 65 - 70
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 57 - 64
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 49 - 56
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 41 - 48
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 35 - 40
published_at 2025-03-28
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 25 - 34
published_at 2025-03-28
Creators :
Satake Keisuke
Kaneko Shuhei
Shimoda Yoshiyuki
Publishers : Faculty of Education, Yamaguchi University
Yamaguchi University Faculty of Global and Science Studies Research Bulletin Volume 1
pp. 61 - 65
published_at 2025-03-01
Yamaguchi University Faculty of Global and Science Studies Research Bulletin Volume 1
pp. 51 - 60
published_at 2025-03-01
Yamaguchi University Faculty of Global and Science Studies Research Bulletin Volume 1
pp. 41 - 50
published_at 2025-03-01
Yamaguchi University Faculty of Global and Science Studies Research Bulletin Volume 1
pp. 31 - 40
published_at 2025-03-01
Yamaguchi University Faculty of Global and Science Studies Research Bulletin Volume 1
pp. 23 - 30
published_at 2025-03-01
Yamaguchi University Faculty of Global and Science Studies Research Bulletin Volume 1
pp. 13 - 22
published_at 2025-03-01
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 17 - 24
published_at 2025-03-28
Creators :
Kasuga Yumi
Kobayashi Nao
Nagaya Kazuhisa
Publishers : Faculty of Education, Yamaguchi University
Yamaguchi University Faculty of Global and Science Studies Research Bulletin Volume 1
pp. 3 - 12
published_at 2025-03-01
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 11 - 16
published_at 2025-03-28
Yamaguchi University Faculty of Global and Science Studies Research Bulletin Volume 1
pp. 1 - 1
published_at 2025-03-01
Bulletin of the Faculty of Education, Yamaguchi University Volume 74
pp. 1 - 9
published_at 2025-03-28
The journal of Yamaguchi area studies Volume 21
pp. 53 - 76
published_at 2024-03-31
The journal of Yamaguchi area studies Volume 21
pp. 37 - 52
published_at 2024-03-31
The journal of Yamaguchi area studies Volume 21
pp. 17 - 36
published_at 2024-03-31
The journal of Yamaguchi area studies Volume 21
pp. 1 - 16
published_at 2024-03-31
Creators :
Wang Meiling
Publishers : The association for Yamaguchi area studies
The journal of Yamaguchi area studies Volume 20
pp. 45 - 64
published_at 2023-03-31
The journal of Yamaguchi area studies Volume 20
pp. 29 - 44
published_at 2023-03-31
Medical Science & Innovation Volume 72 Issue 1-2
pp. 33 - 42
published_at 2025-06
Hypothermia and focal brain cooling (FBC) demonstrate neuroprotective effects in ischemic stroke, but their invasiveness limits clinical use. We explored transient receptor potential (TRP) channels as an alternative, focusing on TRP Ankyrin 1 (TRPA1), which operates within the temperature range of FBC. Activation of TRPA1 has been reported to offer neuroprotection, suggesting it may contribute to the effects seen with FBC. We hypothesized that pharmacological activation of TRPA1 could replicate the neuroprotective effects of FBC, providing a less invasive treatment for cerebral infarction. We examined the effects of a TRPA1 agonist and FBC in focal cerebral ischemia induced by photochemically triggered thrombosis in wild-type (WT) and TRPA1 knockout (KO) mice. In WT mice, intracerebroventricular administration of the TRPA1 agonist allyl isothiocyanate reduced infarct size by approximately half, comparable to FBC. TRPA1 KO mice had larger infarcts than WT, but FBC significantly reduced infarct size in both groups. Furthermore, Evans blue extravasation, used to assess the extent of blood-brain barrier disruption, was approximately twice as high in TRPA1KO mice compared to WT mice. These findings underscore the neuroprotective potential of TRPA1 agonists and the increased vulnerability against ischemia with TRPA1 deficiency. However, the neuroprotective effects of TRPA1 activation are likely mediated by a mechanism distinct from that of FBC. Our study suggests TRPA1 channels are crucial for ischemic stroke protection and may offer a novel therapeutic approach.
Creators :
Okazaki Koki
Oka Fumiaki
Moriyama Hiroshi
Mori Naomasa
Nishimoto Takuma
Inoue Takao
Suzuki Michiyasu
Nomura Sadahiro
Ishihara Hideyuki
Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 72 Issue 1-2
pp. 21 - 31
published_at 2025-06
Focal brain cooling (FBC) at 15℃ and transient receptor potential vanilloid 4 (TRPV4) deficiency relieve brain infarction. TRPV4 channels are inactivated by cooling (< 27℃), suggesting that the anti-ischemic effects of FBC include those of TRPV4 inactivation. However, the extent to which TRPV4 inactivation contributes to the anti-ischemic, anti- blood-brain barrier (BBB) disruption, and anti-apoptosis effects of FBC on cerebral infarction remains unclear. We investigated the contribution and mechanisms of RN1734, a TRPV4 antagonist, in FBC for cerebral infarction using TRPV4 knockout and wild-type mice. Focal cerebral infarction was induced by photochemically induced thrombosis. Infarct volume, BBB disruption, and number of apoptotic cells were evaluated. The TRPV4 antagonist or deficiency showed similar anti-ischemic and anti-BBB disruptive effects to those of FBC. Intracerebroventricular injection of RN1734 showed a similar reduction in the number of apoptotic cells to that of FBC. These anti-ischemic and -apoptotic effects were completely inhibited with injection of GSK1016790A, a TRPV4 agonist, immediately before FBC. Our results showed that TRPV4 modulation is the primary factor contributing to the antiischemic effects of FBC, and TRPV4 channel inactivation relieve focal ischemic infarction by relieving BBB disruption and preventing apoptosis. Therefore, FBC treatment improves ischemic stroke through the modulation of TRPV4 channels.
Creators :
Mori Naomasa
Moriyama Hiroshi
Okazaki Koki
Oka Fumiaki
Fujiyama Yuichi
Shinoyama Mizuya
Nomura Sadahiro
Inoue Takao
Suzuki Michiyasu
Ishihara Hideyuki
Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 72 Issue 1-2
pp. 13 - 20
published_at 2025-06
A 70-year-old woman presented with acute fever, impaired consciousness, leukopenia, thrombocytopenia, and right inguinal lymphadenopathy. A lymph node biopsy was diagnosed as diffuse large B-cell lymphoma (DLBCL). However, her symptoms were consistent with severe fever with thrombocytopenia syndrome (SFTS), and RT-PCR for SFTS virus (SFTSV) RNA was positive. The patient’s condition and lymphadenopathy gradually improved with supportive measures and short-term steroid treatment and no lymphadenopathy recurrence was observed. Lymph node pathological examination revealed SFTSV-infected cells, leading to the final diagnosis of necrotizing lymphadenitis associated with SFTS. Careful consideration is required to differentiate necrotizing lymphadenitis associated with SFTS from that associated with DLBCL.
Creators :
Ando Taishi
Nakano Kohei
Hayashi Shunsuke
Yamashita Kohji
Hatao Katsuhiro
Yamashita Yoshimi
Hirata Yuichiro
Mine Sohtaro
Katano Harutaka
Suzuki Tadaki
Takahashi Toru
Publishers : Yamaguchi University School of Medicine
Medical Science & Innovation Volume 72 Issue 1-2
pp. 7 - 11
published_at 2025-06
Blood-brain barrier (BBB) dysfunction found in the multiple sclerosis (MS) cases is generally considered as a consequence of neuroinflammation. In this study we challenge this view by developing and analyzing novel BBB model from MS patients using induced pluripotent stem cells (iPSCs). We differentiated iPSCs into brain microvascular endothelial cell (BMEC)-like cells to establish an in vitro BBB model. We found that BMEC-like cells from MS patients exhibited compromised barrier integrity, characterized by weakened junctions, heightened permeability, and an elevated inflammatory profile when compared to cells from healthy individuals. Notably, the activation of the Wnt/β-catenin signaling pathway led to improvements in barrier function and a reduction in inflammatory responses, indicating potential therapeutic targets for reinforcing BBB stability in MS.
Medical Science & Innovation Volume 72 Issue 1-2
pp. 1 - 5
published_at 2025-06
Cardiac hypertrophy is widely recognized as a significant risk factor contributing to adverse outcomes in individuals with cardiovascular conditions. The disruption of intracellular calcium ( Ca^{2+} ) balance has been implicated in the development of cardiac hypertrophy, though the precise mechanisms remain poorly understood. In this research, we explored whether hypertrophy induced by pressure overload may arise from the destabilization of the cardiac ryanodine receptor (RyR2) triggered by the dissociation of calmodulin (CaM), leading to subsequent Ca^{2+} leakage. We also assessed whether genetically strengthening the binding affinity between CaM and RyR2 could potentially reverse this process. In the early phases of cardiac hypertrophy caused by pressure overload—when contractile function is still intact—we observed that RyR2 destabilization mediated by reactive oxygen species (ROS) coincides with impaired relaxation. Moreover, stabilizing RyR2 through enhanced CaM binding was found to completely inhibit hypertrophic signaling and improve survival rates. Our findings reveal a crucial connection between RyR2 destabilization and the progression of cardiac hypertrophy.
Creators :
Kohno Michiaki
Kobayashi Shigeki
Yamamoto Takeshi
Yano Masafumi
Publishers : Yamaguchi University School of Medicine
The journal of Yamaguchi area studies Volume 20
pp. 13 - 28
published_at 2023-03-31
The journal of Yamaguchi area studies Volume 20
pp. 1 - 12
published_at 2023-03-31
The journal of Yamaguchi area studies Volume 19
pp. 69 - 84
published_at 2022-03-31
The journal of Yamaguchi area studies Volume 19
pp. 55 - 67
published_at 2022-03-31
The journal of Yamaguchi area studies Volume 19
pp. 35 - 54
published_at 2022-03-31
The journal of Yamaguchi area studies Volume 19
pp. 19 - 34
published_at 2022-03-31
The journal of Yamaguchi area studies Volume 19
pp. 1 - 17
published_at 2022-03-31
The journal of Yamaguchi area studies Volume 18
pp. 45 - 60
published_at 2021-03-31
Creators :
Wang Meiling
Publishers : The association for Yamaguchi area studies
The journal of Yamaguchi area studies Volume 18
pp. 33 - 44
published_at 2021-03-31
Creators :
Kurashige Kayo
Publishers : The association for Yamaguchi area studies
The journal of Yamaguchi area studies Volume 18
pp. 17 - 32
published_at 2021-03-31
The journal of Yamaguchi area studies Volume 18
pp. 1 - 16
published_at 2021-03-31
Bulletin of Clinical Psychology Service Center, Graduate School of Education, Yamaguchi University Volume 15
pp. 23 - 34
published_at 2025-02-28
Bulletin of Clinical Psychology Service Center, Graduate School of Education, Yamaguchi University Volume 15
pp. 11 - 21
published_at 2025-02-28
Bulletin of Clinical Psychology Service Center, Graduate School of Education, Yamaguchi University Volume 15
pp. 3 - 10
published_at 2025-02-28
Bulletin of Clinical Psychology Service Center, Graduate School of Education, Yamaguchi University Volume 15
pp. 1 - 2
published_at 2025-02-28
Yamaguchi Daigaku dokufutsu bungaku Volume 46
pp. 55 - 61
published_at 2024-12-25
Creators :
Shimosaki Masatoshi
Publishers : Yamaguchi University German & French Literature Research Society
Yamaguchi Daigaku dokufutsu bungaku Volume 46
pp. 31 - 53
published_at 2024-12-25
Creators :
Takemoto Masashi
Publishers : Yamaguchi University German & French Literature Research Society
Yamaguchi Daigaku dokufutsu bungaku Volume 46
pp. 1 - 29
published_at 2024-12-25
Creators :
De Boissieu Michel
Publishers : Yamaguchi University German & French Literature Research Society
山口大学学生相談所年報 Volume 33
pp. 36 - 44
published_at 2025-03-31
山口大学学生相談所年報 Volume 33
pp. 25 - 35
published_at 2025-03-31
山口大学学生相談所年報 Volume 33
pp. 12 - 24
published_at 2025-03-31
山口大学学生相談所年報 Volume 33
pp. 5 - 11
published_at 2025-03-31
山口大学学生相談所年報 Volume 33
pp. 2 - 4
published_at 2025-03-31
Yamaguchi journal of economics, business administrations & laws Volume 73 Issue 5
pp. 239 - 260
published_at 2025-01-31
Yamaguchi journal of economics, business administrations & laws Volume 73 Issue 5
pp. 199 - 238
published_at 2025-01-31
Yamaguchi journal of economics, business administrations & laws Volume 73 Issue 5
pp. 181 - 197
published_at 2025-01-31
Creators :
Asamizu Munehiko
Layendra Michell
Publishers : The Economic Society of Yamaguchi University
The philosophical studies of Yamaguchi University Volume 32
pp. 49 - 73
published_at 2025-03-23
The philosophical studies of Yamaguchi University Volume 32
pp. 25 - 48
published_at 2025-03-23
The philosophical studies of Yamaguchi University Volume 32
pp. 1 - 24
published_at 2025-03-23
The philosophical studies of Yamaguchi University Volume 32
pp. 35 - 65
published_at 2025-03-23
Creators :
Yorizumi Mitsuko
Publishers : Yamaguchi University Philosophical Research Society
The philosophical studies of Yamaguchi University Volume 32
pp. 1 - 33
published_at 2025-03-23
Journal of cross-cultural studies Volume 19
pp. 99 - 108
published_at 2025-03-31
Cross-cultural interchange & research institute newsletter Volume 24
pp. 4 - 4
published_at 2024-08-01
Creators :
Kobayashi Hiroshi
Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Journal of cross-cultural studies Volume 19
pp. 87 - 98
published_at 2025-03-31
Creators :
Kawai Hironao
Publishers : The Cross-Cultural Interchange & Research Institute
Cross-cultural interchange & research institute newsletter Volume 24
pp. 3 - 3
published_at 2024-08-01
Creators :
朱 瑩
Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Cross-cultural interchange & research institute newsletter Volume 24
pp. 3 - 3
published_at 2024-08-01
Creators :
古屋 真央
Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Journal of cross-cultural studies Volume 19
pp. 71 - 85
published_at 2025-03-31
Cross-cultural interchange & research institute newsletter Volume 24
pp. 2 - 2
published_at 2024-08-01
Creators :
Kuroha Ryota
Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Cross-cultural interchange & research institute newsletter Volume 24
pp. 1 - 1
published_at 2024-08-01
Creators :
Ueda Yukiko
Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute
Journal of cross-cultural studies Volume 19
pp. 53 - 69
published_at 2025-03-31
Journal of cross-cultural studies Volume 19
pp. 35 - 52
published_at 2025-03-31