- 著者一覧
- Nishihara Hideaki
Nishihara Hideaki
Affiliate Master
Yamaguchi University
Id (<span class="translation_missing" title="translation missing: en.view.desc">Desc</span>)
Medical Science & Innovation Volume 72 Issue 1-2
pp. 7 - 11
published_at 2025-06
Blood-brain barrier (BBB) dysfunction found in the multiple sclerosis (MS) cases is generally considered as a consequence of neuroinflammation. In this study we challenge this view by developing and analyzing novel BBB model from MS patients using induced pluripotent stem cells (iPSCs). We differentiated iPSCs into brain microvascular endothelial cell (BMEC)-like cells to establish an in vitro BBB model. We found that BMEC-like cells from MS patients exhibited compromised barrier integrity, characterized by weakened junctions, heightened permeability, and an elevated inflammatory profile when compared to cells from healthy individuals. Notably, the activation of the Wnt/β-catenin signaling pathway led to improvements in barrier function and a reduction in inflammatory responses, indicating potential therapeutic targets for reinforcing BBB stability in MS.
PloS one Volume 9 Issue 8
pp. e104205 -
published_at 2014-08-08
Creators :
Shimizu Fumitaka
Sawai Setsu
Sano Yasuteru
Beppu Minako
Misawa Sonoko
Nishihara Hideaki
Koga Michiaki
Kuwabara Satoshi
Kanda Takashi
Publishers : Public Library of Science
Clinical neurology Volume 54 Issue 4
pp. 308 - 312
published_at 2014
Creators :
Nishihara Hideaki
Omoto Masatoshi
Ogasawara Junichi
Koga Michiaki
Kawai Motoharu
Kanda Takashi
Publishers : 日本神経学会
PLoS ONE Volume 9 Issue 3
pp. e92872 -
published_at 2014-03-31
Creators :
Shimizu Fumitaka
Tasaki Ayako
Sano Yasuteru
Ju Mihua
Nishihara Hideaki
Oishi Mariko
Koga Michiaki
Kawai Motoharu
Kanda Takashi
Publishers : Public Library of Science