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Nishihara Hideaki

Affiliate Master Yamaguchi University

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Medical Science & Innovation Volume 72 Issue 1-2 pp. 7 - 11
published_at 2025-06
Blood-brain barrier (BBB) dysfunction found in the multiple sclerosis (MS) cases is generally considered as a consequence of neuroinflammation. In this study we challenge this view by developing and analyzing novel BBB model from MS patients using induced pluripotent stem cells (iPSCs). We differentiated iPSCs into brain microvascular endothelial cell (BMEC)-like cells to establish an in vitro BBB model. We found that BMEC-like cells from MS patients exhibited compromised barrier integrity, characterized by weakened junctions, heightened permeability, and an elevated inflammatory profile when compared to cells from healthy individuals. Notably, the activation of the Wnt/β-catenin signaling pathway led to improvements in barrier function and a reduction in inflammatory responses, indicating potential therapeutic targets for reinforcing BBB stability in MS.
Creators : Nishihara Hideaki Publishers : Yamaguchi University School of Medicine
PloS one Volume 9 Issue 8 pp. e104205 -
published_at 2014-08-08
Creators : Shimizu Fumitaka Sawai Setsu Sano Yasuteru Beppu Minako Misawa Sonoko Nishihara Hideaki Koga Michiaki Kuwabara Satoshi Kanda Takashi Publishers : Public Library of Science
PLoS ONE Volume 9 Issue 3 pp. e92872 -
published_at 2014-03-31
Creators : Shimizu Fumitaka Tasaki Ayako Sano Yasuteru Ju Mihua Nishihara Hideaki Oishi Mariko Koga Michiaki Kawai Motoharu Kanda Takashi Publishers : Public Library of Science