The bulletin of the Yamaguchi Medical School
Continued by：Medical Science & Innovation
EISSN：2758-5441
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The bulletin of the Yamaguchi Medical School Volume 42 Issue 1-2
published_at 1995-12
A Case with Neutrophil Infiltration into Nevus Cell Nest after Intravenous Administration of Interferon-β
A Case with Neutrophil Infiltration into Nevus Cell Nest after Intravenous Administration of Interferon-β
Mogami Satoshi
Hirota Toru
Nagai Ko
Okimura Hiroshi
Muto Masahiko
Asagami Chidori
About This Article
Descriptions
Interferon－β therapy has been widely applied for patients with hapatitis C and with malignant melanoma. Its anti-tumor effects on malignant melanoma are well discussed but few reports on anti-tumor effect of the interferon-β to benign tumors are described. A 63-year-old female received interferon-β therapy(dose=6×10 6 units/day) for hepatitis C and developed erythematous change and pain on her intradermal nevus seen on the right external canthus. Histopathological study revealed that the neutrophilic infiltration was localized only in nevus cell nest. It seems interferon-βworked on nevus cells and led the nevocytes to secrete cytokines such as IL-8. A possibility that there is one pathway on anti-tumor effects related to melanin-prpducing cells, via the neutrophils, is suggested.
Creator Keywords
intradermal nevus
interferon
neutrophil
anti-tumor effect
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