A Case with Neutrophil Infiltration into Nevus Cell Nest after Intravenous Administration of Interferon-β
The bulletin of the Yamaguchi Medical School Volume 42 Issue 1-2
Page 45-47
published_at 1995-12
Title
A Case with Neutrophil Infiltration into Nevus Cell Nest after Intravenous Administration of Interferon-β
Creators
Mogami Satoshi
Creators
Hirota Toru
Creators
Nagai Ko
Creators
Okimura Hiroshi
Creators
Muto Masahiko
Creators
Asagami Chidori
Source Identifiers
Creator Keywords
intradermal nevus
interferon
neutrophil
anti-tumor effect
Interferon－β therapy has been widely applied for patients with hapatitis C and with malignant melanoma. Its anti-tumor effects on malignant melanoma are well discussed but few reports on anti-tumor effect of the interferon-β to benign tumors are described. A 63-year-old female received interferon-β therapy(dose=6×10 6 units/day) for hepatitis C and developed erythematous change and pain on her intradermal nevus seen on the right external canthus. Histopathological study revealed that the neutrophilic infiltration was localized only in nevus cell nest. It seems interferon-βworked on nevus cells and led the nevocytes to secrete cytokines such as IL-8. A possibility that there is one pathway on anti-tumor effects related to melanin-prpducing cells, via the neutrophils, is suggested.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1995-12
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部