Storage of Polyvinyl Pyrrolidone --Report of Three Autopsy Cases--

1. Postmortem examination disclosed marked storage of PVP in three patients who had received abundant volume of PVP preparations by intravenous drip infusion. 2. Storage of PVP or derivative of PVP was observed in many organs especially in the reticuloendothelial tissue causing tissue damage of various degree. 3. Morphological changes due to deposit of PVP were characterized by the appearance of ”foam cell” and multinucleated giant cell with frequent formation of granulomatous lesion accompanied by a mild inflammatory exsudate. Deposits of PVP or of its derivative were characteristically stained red to orange with congo red. 4. Electron microscopic study of the liver revealed deposition of PVP not only in the Kupffer cells but in the cytoplasm of the liver cell."