THE STABILIZING ACTION OF CHLORPROMAZINE ON AMPHIBIAN HEART

1. Effects of chlorpromazine were examined on excised toads heart by means of the mechanogramm and the microelectrode technique. 2. Within several minutes after the abministration of chlorpomazine ( 1×10?5g/ml ), the height of contraction and heart rate are lowered approximately in half a value of control. 3. On the heart pre-treated with chlorpromazine ( 1×10?5g/ml ), the conduction block by artificial procedures does not so easily occur comparaed with the non-treated. 4. The membrane potential is lowered by chlorpromazine, the lowering is more marked in the sinus region than the auricular muscle. 5. It is discussed that the stabilization by chlorpromazine may be carried out on the functional level lowered by the drug.