Bartonella henselae infection is a zoonosis found worldwide. Clinical manifestations of B. henselae infection occur on a wide spectrum from typical or classical cat scratch disease (CSD), with regional lymphadenopathy, to atypical or systemic complications. Atypical B. henselae infections include: neuroretinitis, Par inaud's oculoglandular syndrome, hepatosplenic granuloma, and fever of unknown origin. B. henselae infection is not a rare disease in Japan. Performing an indirect fluorescent antibody assay (IFA) to detect antibodies against Bartonella species may provide a prompt diagnosis of Bartonella infection and facilitate appropriate antibiotic therapy.