Atypical Cholecystitis after Bone Marrow Transplantation : Gallbladder Wall Thickening due to Cyclosporine A

A 16-year-old Japanese male with acute mixed lineage leukemia in the second remission underwent allogeneic bone mallow transplantation from a HLA-identical sibling donor. Atypical choleccystitis developed three weeks after transplantation. Abdominal ultrasound examination revealed maked thickening of the gallbladder wall without biliary sludge or gallstones. Cholecystitis was treated by the cessation of cycloporine A three days after symptoms development. To our knowledge, this is the first report of a patient with cyclosporine A induced cholecystitis, that may have been due to direct injury to the gallbladder wall and not a cholestatic mechanism.

cholecystitis

gallbladder wall thickening

bone marrow transplantation

cyclosporine A