This paper reports a rate case of Churg-Strauss syndrome (CSS), in a sixty-five- year old female with 10-year history of bronchial asthma complicated with eosinophilia, pneumonia and later polyneuropathy of sensory and motor disturbances in the extremities. After administration of prednisolone, the eosinophilia and pneumonia promptly ameliorated, however, improvement of the vessel walls infiltrated with inflammatory cells, compatible with vasculitis, and these results suggested the ischemic effect on the nerve fibers as the pathogenesis of polyneuropathy in CSS.