The bulletin of the Yamaguchi Medical School

Continued by:Medical Science & Innovation
EISSN:2758-5441

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The bulletin of the Yamaguchi Medical School Volume 47 Issue 1-2
published_at 2000-06

Expression of an Immunotherapeutic Target Antigen 17-1A for Colorectal Cancer in Multiple Myeloma

Expression of an Immunotherapeutic Target Antigen 17-1A for Colorectal Cancer in Multiple Myeloma
Hayashi Toshiaki
Takahashi Tohru
Adachi Masaaki
Imai Kohzoh
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A020047000104.pdf
Descriptions
A colorectal cancer-associated 17-1A antigen is an effective therapeutic target with monoclonal antibody (mAb) for preventing the recurrence of colorectal cancer. We evaluated its expression in myeloma cell lines and bone marrow cells from patients with multiple myeloma or primary macroglobulinemia by indirect immunofluorescence assays. Antigen 17-1A was shown positive in 3 out of 4 cell lines tested and in 8 out of 9 bone marrow cell specimens including 6 multiple myelomas, one IgG-producing chronic lymphoproliferation and 2 primary macroglobulinemias. These data suggest that adminisration of mAb 17-1A may be a new feasible immunotherapy to those indolent, but incurable diseases.
Creator Keywords
antigen 17-1A
colorectal cancer
monoclonal antibody
multiple myeloma
immunotherapy