Cytokine release during hypoxia/reoxygenation by Kupffer cells in male Wistar rats with obstructive jaundice was in vitro to investigate the kinetics of interleukin-8 (IL-8) release by Kupffer cells during hypoxia/reoxygenation, and to study the influence of endotoxin during the rexygenation period.The rats were divided into two groups : one underwent bile duct ligation (Group OJ)