The Effect of Hyperkalemic Cardioplegia Containing Nitroglycerin or Diltiazem Hydrochloride on Hypertrophied Myocardial Protection.

A hypertrophy heart may be more susceptible to ischemia during cardiac operantions and require better myocardial protection than a normal heart. We hypothesized that cardioplegia containing vasodilator may be effective for hypertrophied myocardial protection. This study was designed to test this hypothesis. Ascending Aorta of Japanese white rabbits, weighing about 1kg, was banded (AoB) to induce mycardial hypertrophy. Three to four months later from AoB, the isolated heart was perfused using the Langendorff technique with Krebs-Henseleit bicarbonate buffer solution for 15 min, and then preserved for 2 hours in cardioplegic arrest by infusing an initial bolus of 20 ml of 4℃ crystalloid cardioplegic solution. The hearts were divided three groups. Cardiac arrest was induced with modified Yamaguchi university crystalloid cardioplegic solution in Group A (n = 10), with that containing nitroglycerin (10-4 mol/L) in Group B (n = 6),and with that containing Ca2+ antagonist (diltiazem hydrochloride

Hypertrophied myocardium

Myocardial protection

Nitroglycerin

Diltiazem hydrochloride