Multiple myeloma with immune thrombocytopenia in an 81-year-old male is reported. He was admitted to our hospital because of paresis of lower extremities. Prednisolone therapy for autoimmune thrombocytopenia was followed by combination therapy (melphalan 8 mg/day + prednisolone 30 mg/day) against multiple myeloma. The platelet count increasedto within normal range and correlated well with a decrease in PAIgG. There was no significant change in total IgG. Intermittent chemotherapy suppressed the proliferation of myeloma cells and maintained the platelet count in the normal range.