We report the case of a 14-year-old girl with suspected Alexander's disease. Magnetic resonance imaging of the brain showed decreased intensity in the frontal white matter on T1-weighted sequences, and an increasd intensity on T2-weighted images. T1-weighted sequences demonstrated an increased attenuation of the basal ganglia, occipital lobes, cerebellum and brainstem. T2-weighted images showed a decreased intensity of the basal ganglia and brainstem. Magnetic resonance imaging is a useful adjunct in establishing a premortal diagnosis of Alexander's disease without brain biopsy.
Alexander's disease
Magnetic resonance imageing
Single photon emission computed tomography(SPECT)