Mutual Correlation of Human Thymocyte Receptors for Phytohemagglutinin, Sheep Red Blood Cell and Specific Antigens

The effects of enflurane anesthesia on the cerebral cortical energy state and glycolytic metabolism were studied in rats. Twenty four rats were devided into four groups with increasing concentrations of enflurane in the arterial blood, I.e., control (1.9±0.3 mg/dl, means±SEM), level I (16.1±1.1 mg/dl), level II (26.0±1.6 mg/dl), and level III (32.9±0.9 mg/dl). At level I, high voltage 1-3 Hz slow waves superimposed with low voltage 10-12 Hz waves were predominant, and at levels II and III, spiking activity and burst suppression were recorded in the EEG. The duration of suppression at level III was significantly longer than that at level II. During enflurane anesthesia, there were no energy change. Glycolytic metabolism remained unchanged except for an increase in glucose at level II and III. Effects of hypocapnia and hypercapnia were examined in additional 12 rats with enflurane concentration in the blood similar to that at level II. Irrespective of Paco_2 levels, there were no significant changes in cerebral energy charge and glycolytic metabolites except for a decrease in glucose and an increase in lactate at hypocapnia. It was concluded that there was neither evidence of derangement of energy state nor increased anaerobic metabolism in the cerebral cortex during enflurane anesthesia.

Thymus

phytohemagglutinin

Antigen

Receptor