The feasibility that membrane action potential in mammalian myocardium can be produced by means of field-stimulation was investigated. Guinea-pig papillary muscle was driven by either point-or field-stimulation and transmembrane potentials were recorded simultaneously by two glass microelectrodes positioned at two different sites of the preparation. Both point-stimulation and weak field-stimulation produced a propagated response, while strong field-stimulation produced a membrane action potential. The present study demonstrated the feasibility of field-stimulation in an induction of membrane action potential in mammalian cardiac muscle.