We have reported on one case of syndrome malin which took a typical course. Serum CPK and LDH showed high values, and changes in them were in agreement with the course of the clinical symptoms. Furthermore NPN and urea N also showed abnormally high values, but they were transient. It is highly posible that deterioration of general conditions and instability of the autonomic nercous system will lead to the development of this syndrome, with parenteral mass-dose administration of psychotropic drugs as a cue. Hence, there is a need to exercise utmost care in this respect.