This report deals with the clinical course of a 52-year-old postmenopausal woman who was diagnosed clinically as subacute hepatitis, but histologically exhibited the co-existence of subacute hepatic necrosis and chronic non-suoourative destructive cholangitis characteristic of the early stage of promaty biliary cirrhosis. This case suggested the possibility of a histological overlap between primary biliary cirrhosis and certain types of hepatitis.