SOME NOTES ON THE LIVER FUNCTION AND ALTERED BIOCHEMICAL ASPECTS IN BACILLARY DYSENTERY

The results of our various clinical laboratory investigations centering around hepatic function in bacillary dysentery in adult may be summarized as follows:1. Hemoglobin level was in 41.4% and hematocrit in 46.4% from slightly to moderately of all The women patients, whereas of The man patients only 17.6% showed lowered hemoglobin and 8.2 % reduced hematocrit level. 2. The serum protein concentration was slighly decreased in 16.7% of 84 patients, and the decrease become increasingly pronounced with The prolongation of clinical course. Serum albumin was decreased in 50.0%, but globulin was increased in 32.1% of 89 patients. The albumin / globulin ratio was reversed in 57.1% of cases. 3. The blood sugar level under fasting conditions was either elevated or lowered in the early satge, but this was not found in the later stage. 4.The cephalin-cholesterol flocculation test was positive in 39.8% of 88patients. 5.The serum icteric index was raised in only 5.1% of 78 paitients. 6.The serum non-protein nitrogen was increased in only 6.4% of 78 patients. 7.Serum alkaline phosphatase, serum total cholesterol, phenol turbidity test and serum inorganci phoshorus remained within normal limits in all the patients exwmined. 8.The serum cholinesterase activity was lowered in 72.1% of 61 cases of bacillus-positive and in considered ti be due not only to the hepatic but to some extrahepatic factors as well. The liver biopsy study of The two paitients in whom The serum cholinesterase activity was markedly reduced showed no noticeable istological changes. 9.The santonin test and The protein-loading urobiliongen test revealed impaiment of detoxicating function of The liver in about a half of the cases. 10.The BSP retention test was carried oun in 19 patients and was found normal except in our, suggesting The exitence of dissocation between The excreting and detoxications of The liver in dysentery. 11.The blood guanidine was markedly elevated in The early stage of The bacillus-positive group, while it was only slghtly elevated in the bacillus-negativ group.