A simple method for The determination of serum sodium by mesns of uranyl zine acetato reagent was developed,introducing a convenient and efficient manipulation of rolling and tapping for the preciptation of sodium as well as employing a glass filter which permits complete purification with ethanol so as to avoild The obstructive effect of potassium after urine was subjected to The preliminary removal of phosphate by zine acetate solution. The divergence in duplicate determination was zero to two per sent for serum sodium and zero to three per cent for urine sodium.The recovery test amounted to 103 per cent on the average,ranging from 93 per cent to 112 per cent.