The Significance of Human Serum Tyrotropin Levels for the Diagnosis and Treatment of the Primary Hypothyroidism

Studies were performed in 8 subjects of primary hypothyroidism. All patients showed variable degree of hypothyroidism in physical features and laboratory tests. Normal value of T3-RSU and PBI was observed in one patient and abnormally low lwvwls of both tests in 4 patients. The radioimmunoassay of TSH was utmost convenient to establish the diagnosis of primary hypothyrodism. High levels of serum TSH were noted in all cases. The highest level of TSH was 10,000 μu/ml, which was noted in juvenile type hypothyroidism (female, 23 yrs. Old). This is also the highest level of TSH among the previous reports. Young persons had a higher levels of TSH omong the previous reports. Young persons had a higher levels of TSH than older ones. Thyroxine and desiccated thyroid were used for replacement therapy. Evaluation of serum TSH was most preferable method to detect the mild hypothyroidism and euthyroid point. There was no correction between the initial levels of TSH and duration required for euthyroidism.