(1) Amyloidosis of the islets in 222 diabetic pancreas was examined by using various stainings, fluorescent microscope, polarized microscope and electron microscope. In l24 cases (55.8 %), amyloidosis of the islets of Langerhans was found, but hyalinization of the islets was not encountered. (2) Amyloid substance was closely situated at the wall of capillaries in the islets and was adjacent to the capillary endothelial cells. (3) Deposit of amyloid in the islet was divided into four types