Effect of Various Antitumor Agents on Electrokinetic Behaviour of Ehrlich’ Ascites Tumor Cells and Mouse Erythrocytes

1. The effects of various antitumor agents on the electrophoretic mobility of Ehrlich' ascites tumor cells and mouse erythrocytes were examined in vitro and in vivo. 2. These antitumor agents had no estimable effect on the electrophoretic behaviour of mouse erythrocyte membrane, while significant decrease was obtained in the electrophoretic mobility of Ehrlich' ascites tumor cells treated with Toyomycin and Mitomycin. 3. The isoelectric point of Ehrlich' ascites tumor cell was supposed to be about pH 4.l. These values indicate that the surfaces of the ascites tumor cells are amphoric and are strongly electronegative at neutral pH. The significant decrease on the electrophoretic mobility of the ascites tumor cells treated with Mitomycin and Tomyocin was obtained mainly on the alkali side of pH. 4. The electrophoretic mobility of the ascites tumor cells was influenced by the ionic strength at pH 7.3. The value decreased according to increase of ionic strength."