Comparative Studies of the Effect of Certain Drugs upon the Liver Functions

Thirteen drugs have been tested for their choleretic activity, biliary excretion of PSP and sulfuthiazole acetrlation ability of the liver. Sodium dehydrocholate (DHC) and reduced sodium dehydrocholate (R-DHC) had a preminent choloretic action, while they had no ability to increase the biliary excretion of PSP and acetylation ability of the liver. Adenine hydrochloride (AND), sodium adenosine triphosphate (ATP), sodium α-(1-hydroxy-cyclohexy1)-butylate (OHBA), para-hydroxy-phenylsalicilamide (PHPS), orotic acid (OTA) and magnecium and potassium aspartate (ASP) had an ability to increase biliary excretion, but the degree of the increasing rate of the liver functions was variable. Sodium ursodesoxycholate (U-DHC), sodium taurodesoxycholate (T-DHC) and 4-amino-5-imidazole caeboxamide (AICA) decreased the sulfathiazole acetylation ability of the liver as well as biliary excretion of PSP. Sodium tioctate (TA) and thiamine-8-(methyl-6-dihydrothioctate)-disulfide hydrochloride (TATD) increased the biliary excretion of PSP and decreased the sulfathiazole acetylation of the liver and the bile excretion.