Electron Microscopic Observation on Human Liver Amyloidosis

Amyloidosis of the liver was diagnosed in a 34-year old male by needle biopsy. Sections of the liver were observed by light microscopy and electron microscopy. By electron microscopy amyloid deposits were recognized in the space of DISSE. Amyloid deposits were shown as filamental structure of about 100 A° in width. Amyloid deposits were found contigunous with deposits and endothelial cells were discussed. (The patient died on 4 April 1959. As the result of autopsy, present case was diagnosed primary generalized amyloidosis. Details of clinical and pathological findings were reported in the Clinic of Digestive Disease 2:412-418,