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いつも「波待ち」 : 不確実性の時代を生きる客家華僑

Cross-cultural interchange & research institute newsletter Volume 23

Creators : Kobayashi Hiroshi Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute Date Issued : 2023-08-01

新型コロナウィルス感染症拡大からみえてきたこと

Cross-cultural interchange & research institute newsletter Volume 23

Creators : Yokota Naotoshi Publishers : Yamaguchi University Faculty of Humanities Cross-cultural interchange & research institute Date Issued : 2023-08-01

巻頭言・目次ほか

Bulletin of Yamaguchi Science Research Center Volume 4

Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Characteristics and Comparative Analysis of Flood Damage Caused by Heavy Rainfall from Baiu-front the 2010 and 2023 in the Asa Area of Sanyo Onoda City

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Yamamoto Haruhiko | Koba Anna Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Characteristics of Flood Damage in Mine City by Heavy Rainfall of Baiu-front in 2023, and Comparative Analysis with Heavy Rainfall in 2010

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Yamamoto Haruhiko | Koba Anna Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Characteristics of Flood Damage in Yamaguchi City by Heavy Rainfall of Baiu-front, 2023

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Yamamoto Haruhiko | Koba Anna Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Estimating Impacts of COVID-19 Business Support Programs on Tourism Industry in Yamaguchi Prefecture

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Yamamoto Shugo | Suwa Tatsuo | Kato Shinya Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Consideration of the Characteristics of Women's Employment in Yamaguchi Prefecture and Measures to Promote Women in the Workforce

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Nabeyama Shoko Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

An attempt to restore physical activity of Yamaguchi University students decreased by COVID-19 disaster : Through PBL activities in collaboration with related departments of the university

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Seino Ryosuke | Tomari Shingo | Hatada Kaho | Fukushima Narumi | Yuasa Hina | Nakai Mina | Ueda Masumi Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Collaborative education by university and regional community: Examples from geocultural studies and events in the Tonomi region in Yamaguchi prefecture

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Hamahashi Mari | Fukui Seiji | Izuho Toshiro | Morishige Yasunobu Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Study about restoration of Shaka-dou Monju Bodhisattva Sitting Statue Pedestal in KOURYUJI Yamaguchi City : Analysis

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Nakano Yoshihisa | Nagashima Mariko | Hirakawa Kazuaki | Morifuku Yoji Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Study about restoration of Shaka-dou Monju Bodhisattva Sitting Statue Pedestal in KOURYUJI Yamaguchi City : Style

Bulletin of Yamaguchi Science Research Center Volume 4

Creators : Uehara Kazuaki | Bana Ryoji Publishers : 山口大学山口学研究センター Date Issued : 2024-07-31

Effect of monoclonal antibody against tnf-alfa on noise-induced inner ear damage

Medical Science & Innovation Volume 71 Issue 1-2

This study investigated the potential of adalimumab (ADA), a monoclonal antibody targeting TNF-alfa, to protect the inner ear from intense sound exposure, given that inflammatory cytokines, including TNF-alfa, are linked to hearing loss in acoustic disorders. In this study, adalimumab was administered to mice, and its effect on the inner ear was assessed. We examined the translocation of ADA to the inner ear and its ototoxicity and impact on acoustic exposure. The results showed that adalimumab partially reached the cochlea after administration but increased the susceptibility to acoustic exposure, resulting in higher hair cell loss in the inner ear. While TNF-alfa had been considered a potential therapeutic target, the results suggested that excessive TNF-alfa suppression could harm the inner ear. We acknowledged some limitations, such as the use of adalimumab instead of an anti-mouse TNF-alfa antibody and the need to explore the suppression of other cytokines for better inner ear protection. In conclusion, adalimumab administration was found to increase the inner earʼs susceptibility to acoustic exposure, potentially leading to more significant hair cell damage, possibly due to excessive TNF-alfa suppression

Creators : 山本陽平 | Sugahara Kazuma | Tsuda Junko | Hashimoto Makoto | Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06

Nobiletin protects hair cells against neomycin-induced vestibular hair cell death

Medical Science & Innovation Volume 71 Issue 1-2

Vestibular hair cells are susceptible to damage from various stimuli such as infections, ischemia, and certain therapeutic drugs, including aminoglycoside antibiotics and the antineoplastic agent cisplatin. In mammals, damage to the vestibular hair cells is permanent. This study aimed to evaluate the protective effects of nobiletin (NOB) against aminoglycoside-induced hair cell death using utricles collected from adult mice. The utricles removed from CBA/N mice were assigned to eight groups according to the dose of NOB and the administration or not of neomycin. Hair cells in the utricles were counted by double labeling with calmodulin and calbindin. NOB inhibited hair cell death in utricles exposed to neomycin. The protective effect of NOB on hair cells in the utricles was also suggested to have resulted from the inhibition of the production and accumulation of 4-hydroxy-2-nonenal, the final product of lipid peroxide aldehyde. NOB suppressed neomycin-induced hair cell death. The principle of hair cell protection from aminoglycoside-induced hair cell death suggests that NOB inhibits reactive oxygen species formation in the utricles exposed to neomycin.

Creators : Masaki Tatsuya | Sugahara Kazuma | Hashimoto Makoto | Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06

Relationship of uric acid and uric acid to creatinine ratio with reduced glomerular filtration rate in non-alcoholic fatty liver disease among apparently healthy adults

Medical Science & Innovation Volume 71 Issue 1-2

Objective: The objective was to explore the potential existence and nature of the relationship between serum of uric acid (SUA) and serum uric acid to serum creatinine ratio (SUA/SCr) with reduced estimated glomerular filtration rate (eGFR) in patients with non-alcoholic fatty liver disease (NAFLD). Methods: A cross-sectional study was conducted among apparently healthy subjects with NAFLD (n=485). The association between tertiles of SUA and SUA/SCr with reduced eGFR (n=56) were investigated after adjustments for potentially relevant confounders. Also, the diagnostic performances of SUA and SUA/SCr were evaluated with the receiver operating characteristic (ROC) curve analysis. Results: In the adjusted models, SUA showed a significant positive association with reduced eGFR in the highest tertile (OR 5.65, 95% CI 2.48-12.86, p<0.001), and SUA/SCr, in the lowest tertile (4.21, 95% CI 1.76-10.07, p=0.001). The ROC curve analysis did not reveal any significant difference between the corresponding values of area under the curve for SUA and SUA/SCr (0.70 and 0.67, respectively; p=0.521). Conclusions: We revealed significant and independent associations of elevated SUA and reduced SUA/SCr with kidney function decline in NAFLD. However, the clinical utility of these two biomarkers seemed to be limited for the mentioned purpose and needs further investigations.

Creators : Shimokawa Junki | Mahbub MH | Yamaguchi Natsu | Hase Ryosuke | Wada Sunao | Saito Hiroyuki | Watanabe Rie | Matsumoto Shoko | Nakagami Yuki | Kurokawa Fumie | Tanabe Tsuyoshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06

Effect of defective calcium metabolism on otolith formation in zebrafish

Medical Science & Innovation Volume 71 Issue 1-2

Benign paroxysmal positional vertigo (BPPV) is the most common vertigo disease and is more likely to occur in perimenopausal women, suggesting an association with osteoporosis. Since otoconia are primarily composed of calcium carbonate, abnormal calcium metabolism may lead to otoconia dislocation. However, the detailed mechanism is currently unknown. In this study, we investigated the effects of drugs (cadmium and dexamethasone) that cause abnormal calcium metabolism on otolith formation in zebrafish larvae. Here, otolith size was clearly reduced in the cadmium group, and the calcium content of the larvae was also markedly reduced. In contrast, in the dexamethasone group, which also had a lower calcium content than the control group, otolith size increased. Our results suggest that, as in bone, calcium metabolism influences the repeated dissolution and recrystallization of otoliths and maintains homeostasis in response to calcium concentrations in the endolymphatic fluid.

Creators : Iwamoto Aya | Sugahara Kazuma | Hashimoto Makoto | Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06

On the right not to be discriminated against

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

Creators : Kajiwara Kensuke Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

The legal definition of academic harassment and power harassment

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

Creators : Yanagisawa Noboru Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

The authenticity of the famous Japanese legend, “abolition of the prohibition law on eating pufferfish in Yamaguchi Prefecture by the first prime minister Hirofumi Ito” : a mystery in the history of pufferfish food hygiene in the Meiji Era

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

Creators : Furukawa Sumiaki Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

Why do Japanese menus have images? Japanese auto-scopophilia is massage not message

Yamaguchi journal of economics, business administrations & laws Volume 72 Issue 6

本研究では、日本のレストランのメニューにはイメージが多い理由を探るために、未知の食事の内容を映像的に知らせるため・映像のなさで高級であることを発信するためという情報伝達仮説と、来客の行動を客体化し欲望を高めるという「マッサージ」（McLuhan、1957）仮説を検証した。情報伝達仮説はいずれも支持されなかったが、マッサージ仮説が有意に支持されたので、既知且つ高級な料理の場合でも、メニューに映像を掲載することを推薦した。

Creators : Takemoto Timothy | Yamauchi Takuma | Horii Kousei | Matsumura Kanta Publishers : The Economic Society of Yamaguchi University Date Issued : 2024-03-31

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