山口医学

Back to Top

山口医学 Volume 29 Issue 3
published_at 1980-09

Pathological Study on Amyloidosis Inhibitory Effects of Various Drugs on Experimental Murine Amyloidosis

アミロイド症の病理学的研究 実験的アミロイド症発生に対する各種薬剤の影響について
Yanagaki Takayuki
Descriptions
The inhibitory effects of various kinds of drugs on inducingmurine amyloidosis were nvestigated. C_3H/He mice were divided into 12 groups and weresubcutaneously administered with Colchine, VitaminA, OK-432, Levamisole, Cepharanthine, Diphtheria toxoid, Dimethyl sulfoxide, Chlorella extract, or Cytochalasin B for a week, respectively. Then, the animals were received a single intraperitoneal injection of a mixture of complete Freund's adjuvant and Microbacterium butyricum followed by countinous administrations of each drug for 10 or 14 days. Detailed histological examination of autopsy spleens and livers provided the following results…