Effects of Butoctamide Hydrogen Succinate and Nitrazepam on Sleep

In the present study, the effects of butoctamide hydrogen succinate (BAHS) and nitrazepam on sleep were studied in 12 healthy male subjects. The subjects were divided into three groups consisting of 4 subjects who were given BAHS 600mg, nitrazepam 5mg, and BAHS 600mg+nitrazepam 5mg, respectively. Polygraphic recordings were made for 8 consecutive nights from each subject. Placebo was given on the first 3 nights and the last 2 nights, and drug was administered on the fourth, fifth, and sixth nights. Before falling asleep and after arising the next morning, the subjects were requested to fill out subjective assessments for sleep. The polysomnogarams were evaluated by computerized automatic analysis using the interval histogram method. The first night was excluded from the data analysis because of the first night effect. BAHS increased REM sleep and decreased stage 2 significantly

セミコハク酸ブトクタミド REM 睡眠

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