on the Surface of Peripheral Blood Lymphocytes after the Dexamethasone Suppression Test : A Study on Patients with Depression, Controls and Young Men

Serum cortisol response to the 1-mg overnight Dexamethasone Suppression Test (DST) was studied on three croups, which were consisted of 12 depressed men (group D) , 12 sex-age matched healthy controls (group C) and 19 healthy young men (group Y). Furthermore, we investigated changes in the ratio of lymphocyte subsets in peripheral blood sampled during the DST, using two-color flowcytometry analysis. The types of lymphocytes according to the combination of surfaceantigens were (1) T/Bcell, (2) CD4/CD8, (3) HLA-DR/CD4 and (4) HLA-DR/CD8. Baseline concentrations of cortisol before the DST were not significantly different between the groups. After the oral administration of dexamethasone, cortisol levels of all subjects except one patient from group D decreased to below 5 /μg/dl. With respect to the ratio of lymphocyte subsets, in group D the baseline ratio of T-lymphocytes associated with CD4. CD8 and HLA-DR was significantly greater than that of the other groups. There was no significant change in each subset after dexamethasone administration. In group C, T-lymphocytes associated with CD8 and HLA-DR significantly increased after dexamethasone administration, and the ratio of CD8^+T-lymphocytes significantly increased in group Y.

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