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Permalink : https://petit.lib.yamaguchi-u.ac.jp/3761
山口医学 Volume 41 Issue 6
published_at 1992-12
Effects of RU 486 on the Early Luteal Function in Pseudopregnant Rats
偽妊娠ラットの初期黄体機能に対するRU486の影響
Kawamoto Kazunori
About This Article
Descriptions
Effects of an anti-progesterone substance, RU 486, on the luteal function were studied in pseudopregnant rats. The 2mg/kg injection RU 486 between day 2 and 9 of pseudopregnancy could not affect on the ovarian function until day 8 (the ascending and the plateau phases) of pseudopregnancy, but did induce luteolysis on day 10 (the descending phase) of pseudopregnancy. On the other hand, the lOmg/kg injection of RU 486 rather induced ovulation, formed new corpora lutea resulted in the increase in serum progesterone levels on day 10 of pseudo- pregnancy. These results indicate that progesterone is an important factor to maintain the pseudopregnancy in rats.
Creator Keywords
ラット
偽妊娠
黄体昨日
プロゲステロン
RU486
Other Article
PP. 387 - 393
PP. 401 - 407
PP. 419 - 428