Immunological Studied of the Esophageal Cancer-The Effect of Immunopotentiators on N-butyl-nitrosourethan-Induced Cancers of the Esophagus and Forestomach of Rats-

Fourty eight Donryu rats were administered N-butyl-N-nitrosourethan (BNUR) in drinking water in a concentration of 0.04% for 30 weeks, and as a result experimental esophageal cancer was induced. Then, immunopotentiators (BCG & OK-432) were injected into the rats, and these groups were compared with the control group. As a result, those receiving OK-432 between the 10th and 30th week, and those receiving it between the 20th and 30th week, after the beginning of BNUR administration showed tumor growth inhibition. But the carcinogenesis rate was 100% in the control group and was 86.5% in the immunotherapeutic groups, respectively, so there was no difference between the two, and the prophylactic effect of immunopotentiators on carcinogenesis was not recognied…