山口医学

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山口医学 Volume 30 Issue 3
published_at 1981-09

The Morphological Changes of the Kupffer Cells and Hepatocytes in Mice after the Administration of Lipopolysaccharide (LPS)

リポ多糖（LPS）投与におけるマウスKupffer細胞及び肝細胞の形態学的変化
Yamashita Yoshimi
About This Article
Descriptions
C3H/He mice treated with LPS were hourly sacrificed to study the morphological changes of the Kupffer cells and hepatocytes. Lght microscopically, the Kupffer cells showed swelling between the 5th and 24th hour. Ultrastructually, the Kupffer cells showed chromatin margination and swollen cytoplasms with many phagosomes containing erythrocytes and platelets etc. In the cytoplasms of hepatocytes, swollen mitochondria with lucent matrix were demonstrated particulary between the 5th and 12th hour, which might show the inhibition of mitochondrial respiration. Autophagosomes, suggesting cellular injuries by LPS, increased in number between the second and 24th hour.…
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