Traditional theories of motion sickness, results of experimental motion sickness and our hypotheis were summarized. Since motion sickness is evoked by abnormality of spatial orientation, it involves not only discomfort but also equilibrium ataxia as an alarm and regulation disorder, respectively. When loss of spatial orientation is not accompanied with discomfort, uncontrolled actions could become dangerous. The possibility that reproduction of the surrounding space in the brain automatically modifies motor programs has been supported by the findings of Coriolis-induced eye movements.