The Relationship between Frontal Midline Theta Activity and Dopaminergic Functions in Chronic Schizophrenia

The distinct EEG theta rhythm from the frontal midline area during the performance of a mental task is referred to as Fmθ , and may possible be correlated with decrease in dopamine (DA) function or D2 receptor sensitivity in normal humans. In the present study, the relationship between the appearance of Fmθ and DA functions was investigated in 50 male inpatients with chronic schizophrenia. The scores of positive and negative syndrome scale (PANSS) and EEGs during arithmetic addition were recorded once weekly until Fmθ could be detected two times in succession during a period of 10 weeks. Plasma DA and HVA and serum PRL were measured before and after the test. Fmθ was observed in 32 patients, the Fmθ group, but not 18 patients comprising the non-Fmθ group. In the Fmθ group, positive, negative and general psychiatric symptoms improved after the test, and DA and HVA increased while PRL decreased after the test. In the non-Fmθ group, positive symptoms and DA, HVA and PRL after the test were essentially the same as before, but negative and general psychiatric symptoms had worsened. Fm d should thus prove useful for predicting the prognosis of schizophrenics. DA functions of the non-Fmθ group were found higher than those of the Fm θ group.

精神分裂病

ドーパミン神経活動

抗神経病薬

治療反応性

ストレス

前頭正中部θ律動（Fmθ)