Serum Level of Phenytoin Products Used in Yamaguchi University Hospital

The relationships of serum phenytoin level with odse, age and formulation, respectively, were investigated using 107 data of 82 patients medicated with commercial antiepileptics from September 1978 to Feburuary 1981 in Yamaguchi University Hospital and the in vitro dissolution profiles of there products, i. e. Aleviation^〇!R (pure powder), Aleviatin^〇!R tablet and Diphenylhydantoin^〇!R powder (10%), 1. The serum phenytoin levels didn't reach to the therapeutic levels (10-20 μg/ml in adult and 5-20 μg/ml in child) regardless to age, formulation and brand when dosed under 4mg/kg/day. …