The patient, a 18-year-old female, was suffering from lupus nephritis and her laboratory test showed abnormal retention of indocyanine green but[ BSP test was normal. No other liver function tests were abnormal. Not only the patient but her father amd her younger brother showed an ICG test was abnormal but a BSP test was normal and other liver function tests were normal, so this phenomenon of discrepancy between ICG test and BSP test seemed familial trait. Though none of the family members have a past history or present illness of liver disease or congential jaundice, they do have photosensitive dermatitis or contact dermatitis familially. We reported a familial trait of discrepancy between ICG test and BSP test.