山口医学

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山口医学 Volume 26 Issue 3
published_at 1977-12

Effects of ATP Preparation Myoactin C on the Smooth Muscle

平滑筋におけるATP製剤”ミオアクチンC”の作用について
Yamauchi Hisao
Yasumoto Tatsuo
Suenaga Tadahiro
Yamanouchi Takashi
Descriptions
The author has studied the effects of ATP preparation MYOACTIN C on the smooth muscle (small intestine and carotid artery) physiologially. MYOACTIN C is composed of ATP, L-cystine and L-tyrosine, as fix combination drugs. Results of experiments. The author observed that ATP increased the tone of the smooth muscle at a low concentration and decreased it at a high concentration. The effect by L-tyrcsine or L-cystine was faint on the smooth muscle, but L-tyrosine+L-cystine made to fall the tone.Though some ATP preparatitons on the market showed a remarkable fall of tone strongly and decreased the phasic concentration amplitude. The effects of MYOACTIN C on the smooth muscle can be considered that they relate closely with L-Tyosine+L-cystine. The effects of MYOACTIN C are also investigated at the combined administration of tetrodotoxin (10^-6g/ml), phenoxybenzamin, an adrenargic nerve-blocker (5×10^-6g/ml), pimdolol (2×10^-6g/ml) and also atropin, a cholinergic blocker (5×10^-6g/ml) , respectively